Use of Human Pluripotent Stem Cell-derived Macrophages to Improve Tissue Integration

Mentor: Kory Lavine, Assistant Professor of Internal Medicine

Lab description: Our laboratory is interested in understanding how the immune system can be manipulated to reduce inflammation, improve tissue healing, and leveraged to develop regenerative approaches.

Project: This project will explore the functions of human pluripotent stem cells-derived macrophages within the mouse heart. Key areas of interest will include how transplanted macrophages influence the organization, morphology, and transcriptional signatures of native endothelial cells, fibroblasts, and cardiomyocytes.